c-di-GMP Inhibits Early Sporulation in Clostridioides difficile
Adrianne N. Edwards, Caitlin L. Willams, Nivedita Pareek, Shonna M. McBride, Rita Tamayo
Abstract
Many bacterial organisms utilize the small signaling molecule cyclic diguanylate (c-di-GMP) to regulate important physiological processes, including motility, toxin production, biofilm formation, and colonization. c-di-GMP inhibits motility and toxin production and promotes biofilm formation and colonization in the anaerobic, gastrointestinal pathogen Clostridioides difficile . However, the impact of c-di-GMP on C. difficile spore formation, a critical step in this pathogen’s life cycle, is unknown.
Topics & Concepts
IntracellularMicrobiologyBiofilmSporeBiologyPathogenMutantSignal transductionGeneCell biologyChemistryGeneticsBacteriaClostridium difficile and Clostridium perfringens researchGut microbiota and healthNosocomial Infections in ICU