YTHDF2 favors protumoral macrophage polarization and implies poor survival outcomes in triple negative breast cancer
Hao Jin, Yue Chen, Dongbo Zhang, Junfan Lin, Songyin Huang, Xiaohua Wu, Wen Deng, Jiandong Huang, Yandan Yao
Abstract
-high macrophages, providing potential therapeutic targets for new strategies. In conclusion, YTHDF2 in macrophages appears to promote pro-tumoral effects while suppressing immune activity, indicating the treatment targeting YTHDF2 or its transcription factors could be a promising strategy for chemoresistant TNBC.
Topics & Concepts
Triple-negative breast cancerMacrophage polarizationBreast cancerMacrophageCancer researchChemistryCancerMedicineInternal medicineBiochemistryIn vitroRNA modifications and cancerEpigenetics and DNA MethylationFerroptosis and cancer prognosis