Synthesis and antibacterial activity of chalcone derivatives containing thioether triazole
Ying Chen, Pu Li, Mei Chen, Jun He, Shijun Su, Ming He, Hua Wang, Wei Xue
Abstract
Abstract The infection of Xanthomonas oryzae pv. Oryzae ( Xoo ), Ralstonia solanacearum ( Rs ), and Xanthomonas axonopodis pv. Citri ( Xac ) has become a major problem in agricultural production. In this study, a series of novel chalcone derivatives containing thioether triazoles were designed and synthesized. The structures of the novel compounds were systematically characterized via 1 H‐NMR, 13 C‐NMR, and HRMS. Moreover, the antibacterial activity results showed that E 10 , E 11 , E 15 , and E 16 have adequate antibacterial activities against Xoo , Rs , and Xac . Among the different compounds, E 15 exhibited remarkable inhibitory effect against Xac with an EC 50 of 9.1 μg.mL ‐1 , which was better than that of commercial agent bismerthiazol (54.9 μg.mL ‐1 ). In addition, the possible antibacterial mechanism of the target compound E 15 against Xac was studied via scanning electron microscopy (SEM).