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Perinatal loss of galactosylceramidase in both oligodendrocytes and microglia is crucial for the pathogenesis of Krabbe disease in mice

Jacob Favret, Mohammed Haseeb Nawaz, Mayuri Patel, Hamid Khaledi, Michael H. Gelb, Daesung Shin

2024Molecular Therapy10 citationsDOIOpen Access PDF

Topics & Concepts

MicrogliaNeuroinflammationKrabbe diseaseBiologyCell biologyImmunologyAstrocytePathogenesisImmune systemPhenotypeTREM2LeukodystrophyNeuroscienceCentral nervous systemInflammationDiseasePathologyMedicineGeneticsGeneLysosomal Storage Disorders ResearchNeuroinflammation and Neurodegeneration MechanismsAutism Spectrum Disorder Research
Perinatal loss of galactosylceramidase in both oligodendrocytes and microglia is crucial for the pathogenesis of Krabbe disease in mice | Litcius