Synthesis of 4-(arylthio)isoquinolin-1(2 <i>H</i> )-ones <i>via</i> TBHP-mediated sequential amidation/thioetherification of <i>N</i> -alkylisoquinolinium salts
Chuanquan Chu, Chuanquan Chu, Lijuan Jin, Yilin Chen, Dahan Wang, Jinbing Liu, Junyuan Tang, Zi Yang, Mingming Yu, Jinhui Cai
Abstract
)-ones in 30-92% yields. The potential synthetic utility is demonstrated by its gram-scale synthesis and derivatizations. The mechanistic experiments indicate that the iodide plays a key role in this transformation.
Topics & Concepts
IodideCombinatorial chemistryChemistrySimple (philosophy)Organic chemistryEpistemologyPhilosophySynthesis of heterocyclic compoundsQuinazolinone synthesis and applicationsSulfur-Based Synthesis Techniques