Biomineralization-inspired synthesis of amorphous manganese phosphates for GLUT5-targeted drug-free catalytic therapy of osteosarcoma
Chunlin Zhang, Jianping Hu, Yingying Jiang, Shuo Tan, Kunpeng Zhu, Chao Xue, Yunlu Dai, Feng Chen
Abstract
, our Fru-MnP nanoplatform also acts as an effective tumour-specific MRI contrast agent, realizing the MRI-monitored chemodynamic therapy. The proposed synergistic therapeutic platform opens new possibilities for high efficacy therapy for osteosarcoma.
Topics & Concepts
OsteosarcomaCancer researchBiomineralizationChemistryEndocytosisCancer therapyCellCancerMedicineBiochemistryBiologyInternal medicinePaleontologyNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismNanoparticle-Based Drug Delivery