Clinical Performance of the RealTi <i>m</i> e High Risk HPV Assay on Self-Collected Vaginal Samples within the VALHUDES Framework
Ardashel Latsuzbaia, Davy Vanden Broeck, Severien Van Keer, Steven Weyers, Wiebren Tjalma, Jean Doyen, Gilbert Donders, P. De Sutter, Alex Vorsters, Eliana Peeters, Marc Arbyn
Abstract
e High Risk HPV assay (Abbott RT) on two different vaginal devices to detect cervical intraepithelial neoplasia grade two or higher (CIN2+). The study results demonstrated that the Abbott RT assay is similarly accurate on vaginal self-samples as on matched clinician-taken cervical samples after adjusting cutoff values. Moreover, we observed that some vaginal devices perform better than others in CIN2+ detection. We also underline the necessity of standardization and validation of general workflow and sample handling procedures for vaginal self-samples.
Topics & Concepts
ColposcopyMedicineCutoffGynecologyConfidence intervalCervical cancerObstetricsInternal medicineCancerQuantum mechanicsPhysicsCervical Cancer and HPV ResearchReproductive tract infections researchMolecular Biology Techniques and Applications