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MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage

Peter Kalev, Marc L. Hyer, Stefan Größ, Zenon Konteatis, Chi-Chao Chen, Mark P. Fletcher, Max Lein, Elia Aguado-Fraile, Victoria Frank, Amelia Barnett, Everton Mandley, Joshua E. Goldford, Yue Chen, Katie Sellers, Sebastian Hayes, Kate Lizotte, Phong Quang, Yesim Tuncay, Michelle Clasquin, Rachel Peters, Jaclyn Weier, Eric Simone, Joshua Murtie, Wei Liu, Raj Nagaraja, Lenny Dang, Zhihua Sui, Scott A. Biller, Jeremy Travins, Kevin M. Marks, Katya Marjon

2021Cancer Cell234 citationsDOI

Topics & Concepts

RNA splicingMessenger RNADNA damageDNACancer cellCell biologyCancerAlternative splicingBiologyCancer researchChemistryGeneRNAGeneticsCancer-related gene regulationEpigenetics and DNA Methylation
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage | Litcius