Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
Luciana P. Tavares, Thayse R. Brüggemann, Rafael M. Rezende, Marina Machado, R. Cagnina, Ashley E. Shay, Cristiana Couto Garcia, Julie Nijmeh, Mauro Martins Teixeira, Bruce D. Levy
Abstract
Secondary bacterial pneumonia is a serious and common complication of IAV infection, leading to excess morbidity and mortality. New host-directed approaches are needed to complement antibiotics to better address this important global infectious disease. Here, we show that harnessing endogenous resolution mechanisms for inflammation by exogenous administration of a family of specialized proresolving mediators (i.e., cys-MCTRs) increased macrophage resilience mechanisms after IAV to protect against secondary infection from Streptococcus pneumoniae.
Topics & Concepts
Streptococcus pneumoniaeMicrobiologyVirusVirologyInfluenza A virusBiologyImmunologyAntibioticsInfluenza Virus Research StudiesImmune Response and Inflammationinterferon and immune responses