Glucose reduced nano-Se mitigates Cu-induced ROS by upregulating antioxidant genes in zebrafish larvae
S. Umapathy, Ieshita Pan
Abstract
) and nitric oxide levels (6.71 μM). They also had the potential to restore cognitive properties such as larval movement (93.40 m) without altering larval behaviour. Live cell imaging indicated a significant decrease in cellular reactive oxygen species and lipid peroxidation levels in the gut and liver. These findings suggest that Se-NPs reduced for 30 minutes with d-glucose are promising candidates for oxidative stress-induced neurodegeneration.
Topics & Concepts
ZebrafishAntioxidantGeneReactive oxygen speciesDownregulation and upregulationNano-Cell biologyLarvaBiologyChemistryBiochemistryEcologyMaterials scienceComposite materialSelenium in Biological SystemsNanoparticles: synthesis and applicationsAdvanced Nanomaterials in Catalysis