High risk of microscopic colitis after <i>Campylobacter concisus</i> infection: population-based cohort study
Hans Linde Nielsen, Hans Linde Nielsen, Michael Dalager‐Pedersen, Henrik Nielsen, Henrik Nielsen
Abstract
Objective Microscopic colitis (MC) encompasses the two histopathological distinct entities of collagenous colitis (CC) and lymphocytic colitis (LC). In this Danish population-based cohort study, we examined the risk of MC following stool culture with Campylobacter concisus , C. jejuni , non-typhoidal Salmonella or a culture-negative stool test. Design We identified patients with a first-time positive stool culture with C. concisus , C. jejuni , non-typhoidal Salmonella or negative stool test, from 2009 through 2013 in North Denmark Region, Denmark, and matched each with 10 population comparisons. All subjects were followed up until 1 March 2018 using Systematised Nomenclature of Medicine codes from The Danish Pathology Register for incident diagnoses of CC and LC. We computed risk and adjusted HRs with 95% CIs for MC among patients and comparisons. Results We identified 962 patients with C. concisus , 1725 with C. jejuni , 446 with Salmonella and 11 825 patients with culture-negative stools. The MC risk and HR versus comparisons were high for patients with C. concisus (risk 6.2%, HR 32.4 (95% CI 18.9 to 55.6)), less for C. jejuni (risk 0.6%, HR 3.7 (95% CI 1.8 to 7.7)), low for Salmonella (risk 0.4%, HR 2.2 (95% CI 0.5 to 10.8)) and for patients with negative stool testing (risk 3.3%, HR 19.6 (95% CI 16.4 to 23.4)). After exclusion of the first year of follow-up, the HRs were 9.3 (95% CI 4.1 to 20.1), 2.2 (95% CI 0.9 to 5.4), 1.3 (95% CI 0.2 to 11.1) and 5.6 (95% CI 4.6 to 7.2), respectively. Conclusion A high risk of MC was observed following C. concisus in stools. Further studies are needed to elucidate any underlying biological mechanisms.