An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
Ke Pei, Ting Gui, Dongfang Kan, Huichao Feng, Yanqiang Jin, Ying Yang, Qian Zhang, Ziwei Du, Zhibo Gai, Jibiao Wu, Yunlun Li
Abstract
The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.
Topics & Concepts
Nonalcoholic fatty liver diseaseLipid metabolismFatty liverCeramideInternal medicineArachidonic acidMetabolismMedicineEndocrinologyDiseaseFatty acidBiologyBiochemistryEnzymeApoptosisLiver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseLipid metabolism and biosynthesis