Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism
Yong Zhao, Shengbo Han, Zhu Zeng, Hai Zheng, Li Yang, Fan Wang, Yan Huang, Yingsong Zhao, Wenfeng Zhuo, Guozheng Lv, Hongda Wang, Guangyu Zhao, Eryang Zhao, Yuhang Hu, Ping Hu, Gang Zhao
Abstract
Our results indicated the pivotal role of lipid metabolism-related and liver-specific HNF4A-AS1 in inhibiting sorafenib resistance by promoting ferroptosis and suggesting that HNF4A-AS1 might be a potential target for HCC.
Topics & Concepts
ReprogrammingHepatocellular carcinomaSorafenibCancer researchLipid metabolismMetabolismChemistryCell biologyBiologyBiochemistryGeneRNA modifications and cancerCancer-related molecular mechanisms researchFerroptosis and cancer prognosis