Perioperative assessment of muscle inflammation susceptibility in patients with end-stage osteoarthritis
Devin Drummer, Jeremy S. McAdam, Regina Seay, Inmaculada Aban, Kaleen M. Lavin, Derek A. Wiggins, Gabriel Touliatos, Sufen Yang, Christian Kelley, S. Craig Tuggle, Brandon Peoples, Herrick J. Siegel, Elie Ghanem, Jasvinder A. Singh, Scott Schutzler, C. Lowry Barnes, Arny A. Ferrando, S. Louis Bridges, Marcas M. Bamman
Abstract
This study assessed the skeletal muscle molecular characteristics associated with end-stage osteoarthritis and refined an important phenotype, in some patients, termed muscle inflammation susceptibility (MuIS+) that may be an important consideration following surgery. Furthermore, we provide evidence of differential inflammatory and catabolic gene expression between the contralateral and surgical limbs along with differences between the skeletal muscle surrounding the diseased hip versus knee joints.