Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the <i>PTEN</i> Promoter
Xiaocong Lin, Guodan Li, Xiuwen Yan, Weiyu Fu, Jie Ruan, Hang Ding, Huajun Yu, Xiaoyi Chen, Liubo Lan, Yong Dai, Kai Pan, Xinguang Liu, Haitao Zhang
Abstract
promoter. Our study advances the understanding of the role of BC002811 in the pathogenesis of GC and provides new molecular targets for therapeutic intervention against GC metastasis.
Topics & Concepts
PTENCancer researchBiologyMetastasisDownregulation and upregulationSOX2Long non-coding RNATranscription factorCell growthCancerApoptosisGenePI3K/AKT/mTOR pathwayGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCholangiocarcinoma and Gallbladder Cancer Studies