Visible-Light-Promoted bis(Difluoromethylation)/Cyclization of 2-Vinyloxy Arylalkynes to Prepare Benzofuran Derivatives
Huan Wang, Yao Huang, Qiaoyan Wu, Jun Lu, Yanli Xü, Yanyan Chen
Abstract
A visible-light-promoted difluoromethylation/cyclization of 2-vinyloxy arylalkynes was developed, providing a variety of bis(difluoromethyl)-substituted benzofurans in moderate to good yields. A plausible mechanism involving difluoromethyl radical cascade cyclization and solvent-promoted ionic addition was proposed. This protocol has the advantages of having mild reaction conditions, simple operation, and good functional group tolerance.
Topics & Concepts
ChemistryBenzofuranCombinatorial chemistryIonic bondingMedicinal chemistryOrganic chemistryIonFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques