Model-Informed Precision Dosing of Vancomycin in Adult Patients Undergoing Hemodialysis
Kazutaka Oda, Hirofumi Jono, Hideyuki Saito
Abstract
dosing for vancomycin-a loading dose of 30 mg/kg, which achieves the target AUC for 24 h after first dose with a probability of 93.0%, ensured by a predialysis concentration of >15 μg/mL. Maintenance doses of 12 mg/kg after every hemodialysis session could achieve the required exposure, with a probability of 80.6%. In conclusion, this study demonstrated that KoA-predicted hemodialysis clearance may lead to an upgrade from conventional dosing to MIPD for vancomycin in patients undergoing hemodialysis.
Topics & Concepts
DosingHemodialysisMedicineVancomycinMeropenemPharmacokineticsPopulationDialysisUrologySurgeryInternal medicineAntibioticsBiologyStaphylococcus aureusEnvironmental healthMicrobiologyAntibiotic resistanceGeneticsBacteriaAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility Testing