Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers
Eslam M. Abbass, Ali Kh. Khalil, Mohamed Mokhtar Mohamed, Ibrahim H. Eissa, Abeer M. El‐Naggar
Topics & Concepts
ChemistryApoptosisStereochemistryDocking (animal)DoxorubicinIC50QuinoxalineLead compoundIn vitroDNACell cultureBiochemistryBiologyMedicineGeneticsNursingOrganic chemistryChemotherapySynthesis and Biological EvaluationCancer therapeutics and mechanismsBioactive Compounds and Antitumor Agents