PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
Dean Thumkeo, Siwakorn Punyawatthananukool, Somsak Prasongtanakij, Ryuma Matsuura, Kentaro Arima, Huan Nie, Rie Yamamoto, Naohiro Aoyama, Hisao Hamaguchi, Shingo Sugahara, Shinobu Takeda, Varodom Charoensawan, Atsushi Tanaka, Shimon Sakaguchi, Shuh Narumiya
Abstract
-EP2/EP4 signaling functions as the key regulatory node linking active inflammation and immunosuppression in TME, which can be targeted by EP2 and EP4 antagonists for cancer therapeutics.
Topics & Concepts
InflammationImmunosuppressionTumor microenvironmentImmune systemCancer researchImmunologyBiologySignal transductionProstaglandin E2 receptorCell biologyReceptorBiochemistryAgonistImmune cells in cancerImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers