L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase
Jonathan Blachier, Aurore Cleret, Nathalie Guérin, Clara Gil, Jean-Marc Fanjat, Florian Tavernier, Laura Vidault, Fanny Gallix, Nicolas Rama, Rodrigue Rossignol, Diana Piedrahita, Aurély Andrivon, Marie Châlons-Cottavoz, Karine Aguéra, Fabien Gay, Françoise Horand, Bastien Laperrousaz
Topics & Concepts
AsparaginaseAsparagine synthetaseGlutaminaseBiologyGlutaminePancreatic cancerCancer researchAsparagineEnzymeCancerBiochemistryLeukemiaImmunologyLymphoblastic LeukemiaAmino acidGeneticsCancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology ResearchEpigenetics and DNA Methylation