A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation
Monique T. Fonseca, Eduardo Hermógenes Moretti, Lucas Maciel Mauriz Marques, Bianca F. Machado, Camila F. Brito, Jady T. Guedes, Evilin Naname Komegae, Thayna S. Vieira, William T. Festuccia, Norberto Peporine Lopes, Alexandre A. Steiner
Abstract
receptors. These findings provide a framework to understand how systemic inflammation can be regulated at the level of interorgan communication.
Topics & Concepts
InflammationSpleenSystemic inflammationTumor necrosis factor alphaLeukotriene B4ImmunologyLeukotrieneGranulomatous inflammationMedicinePathologyAsthmaInflammasome and immune disordersImmune Response and InflammationVagus Nerve Stimulation Research