Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery
Kazuaki Maruyama, Kazuaki Naemura, Yuichiro Arima, Yasunobu Uchijima, Hiroaki Nagao, Kenji Yoshihara, Manvendra K. Singh, Akiyoshi Uemura, Fumio Matsuzaki, Yutaka Yoshida, Yukiko Kurihara, Sachiko Miyagawa‐Tomita, Hiroki Kurihara
Abstract
analyses demonstrated that Sema3E may demarcate areas to repel PlexinD1-expressing lymphatic endothelial cells, resulting in proper coronary and lymphatic vessel formation. Furthermore, inactivation of Sema3E-PlexinD1 signaling improved the recovery of cardiac function by increasing reactive lymphangiogenesis in an adult mouse model of myocardial infarction. These findings may lead to therapeutic strategies that target Sema3E-PlexinD1 signaling in coronary artery diseases.
Topics & Concepts
LymphangiogenesisLymphatic systemSemaphorinLymphatic EndotheliumMyocardial infarctionMedicineLymphatic vesselCardiologyArteryInternal medicinePathologyReceptorMetastasisCancerCongenital heart defects researchAxon Guidance and Neuronal SignalingLymphatic System and Diseases