Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon
Marwa Mohamed El Sayed, Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Amr S. Abu Lila, Nehal E. Elsadek, Eman Alaaeldin, Yu Ishima, Hidenori Ando, Amal Kamal, Hatem A. Sarhan, Tatsuhiro Ishida
Topics & Concepts
LiposomeSpleenPEG ratioIn vivoChemistryPharmacologyImmunologyIn vitroMedicineBiologyBiochemistryBiotechnologyFinanceEconomicsImmunotherapy and Immune ResponsesNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery