Litcius/Paper detail

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

Bo Yan, Youwei Ai, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang

2020Molecular Cell578 citationsDOIOpen Access PDF

Topics & Concepts

Lipid peroxidationReactive oxygen speciesHydrogen peroxideBiochemistryGPX4BiologyAntioxidantCytochrome b5ReductasePolyunsaturated fatty acidOxidoreductaseNAD+ kinaseMembrane lipidsPhospholipid-hydroperoxide glutathione peroxidaseCell biologyMembraneEnzymeFatty acidCatalaseGlutathione peroxidaseDrug Transport and Resistance MechanismsCancer, Lipids, and MetabolismFerroptosis and cancer prognosis