Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc−/GSH/GPX4 axis
Fangfang Yu, Juan Zuo, Miao Wang, Shui-yuan Yu, Kangting Luo, Tong-tong Sha, Quan Li, Zai-chao Dong, Guoyu Zhou, Feng Zhang, Xiong Guo, Yue Ba, Yanjie Wang
Abstract
/GSH/GPX4 axis, thereby antagonizing ferroptosis of chondrocytes and alleviating articular cartilage damage. In conclusion, our findings highlight the essentiality of ferroptosis in chondrocyte caused by T-2 toxin, elucidate how Se-Met offers protection against this injury and provide research evidence for the drug treatment target of Kashin-Beck disease.
Topics & Concepts
ToxinGPX4GlutathioneSeleniumChemistryOxidative stressArticular cartilageBiologyBiochemistryMedicinePathologyEnzymeOrganic chemistryGlutathione peroxidaseAlternative medicineOsteoarthritisCancer-related molecular mechanisms researchExtracellular vesicles in diseaseFerroptosis and cancer prognosis