Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
Jiajun Liu, Shumin Li, Xuefeng Fei, Xi Nan, Yingying Shen, Huiqing Xiu, Stephania A. Cormier, Chaojie Lu, Chuqi Guo, Shibo Wang, Zhijian Cai, Pingli Wang
Abstract
siRNA; EMT: epithelial-mesenchymal transition; HBE: human bronchial epithelial; HCQ: hydroxychloroquine; MAPK: mitogen-activated protein kinase; NAC: N-acetyl-L-cysteine; NFKB: nuclear factor of kappa light polypeptide gene enhancer in B cells; NS: normal saline; PM: particulate matter; ROS: reactive oxygen species; TRAF6: TNF receptor-associated factor 6; TRIM37: tripartite motif-containing 37.
Topics & Concepts
AutophagyCancer researchMetastasisLungUbiquitin ligaseLung cancerBiologyGene knockdownChemokineUbiquitinInflammationImmunologyCancerMedicinePathologyApoptosisInternal medicineBiochemistryGeneticsGeneImmune cells in cancerOccupational and environmental lung diseasesHeme Oxygenase-1 and Carbon Monoxide