<i>Lactobacillus plantarum</i> TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet <i>via</i> modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota
Te‐Hua Liu, Guan-Li Chen, Chih‐Hui Lin, Tsung‐Yu Tsai, Mengchun Cheng
Abstract
< 0.05). Analysis of SCFA content in fecal samples revealed a significant increase in SCFA concentrations, particularly acetic acid, following administration of both TWK10 and its fermented soy milk. Finally, TWK10 was found to modulate the composition of the intestinal microbiota and increase microbial diversity. In conclusion, TWK10 and its fermented soy milk effectively alleviated loperamide-induced constipation in rats fed a high-fat diet. These findings suggest that TWK10 and its fermented soy milk may potentially be functional foods for promoting intestinal health.
Topics & Concepts
LoperamideGut floraConstipationDiarrheaLactobacillusLactobacillus plantarumBiologyInternal medicineFood sciencePharmacologyMedicineFermentationBiochemistryBacteriaLactic acidGeneticsGastrointestinal motility and disordersInfant Health and DevelopmentGut microbiota and health