Hepatic PRMT1 ameliorates diet-induced hepatic steatosis via induction of PGC1α
Lu Xu, Zhe Huang, Tak-Ho Lo, Jimmy Tsz Hang Lee, Ranyao Yang, Xingqun Yan, Dewei Ye, Aimin Xu, Chi‐Ming Wong
Abstract
Rationale: Over-nutrition will lead to overexpression of PRMT1 but protein hypomethylation is observed in the liver of obese subjects. The dynamic alteration of the expression and methyltransferase activity of PRMT1 in the progression of fatty liver diseases remains elusive. Methods: We used recombinant adeno-associated virus-mediated gene delivery system to manipulate the hepatic PRMT1 expression level in diet-induced obese mice to investigate the role of PRMT1 in hepatic steatosis. We further utilized a cohort of obese humans with biopsy-proven nonalcoholic fatty liver disease to support our observations in mouse model.
Topics & Concepts
SteatosisInternal medicineChemistryEndocrinologyMedicineGastroenterologyCancer-related gene regulationPancreatic function and diabetesDiabetes Treatment and Management