Spatio-temporally deciphering peripheral nerve regeneration <i>in vivo</i> after extracellular vesicle therapy under NIR-II fluorescence imaging
Yueming Wang, Huaixuan Sheng, Cong Meng, Wenjin Wang, Qianru He, Huizhu Li, Shunyao Li, Jian Zhang, Yuzhou Chen, Shuaicheng Guo, Lu Fang, Stefano Pluchino, Ewelina Biskup, Mikhail Artemyev, Fuchun Chen, Yunxia Li, Jun Chen, Sijia Feng, Yan Wo
Abstract
In this study, a new non-invasive near-infrared fluorescence imaging strategy based on glucose-conjugated quantum dots (QDs-Glu) labeling to target and track EVs in a sciatic nerve injury rat model in real-time was introduced.
Topics & Concepts
FluorescenceIn vivoRegeneration (biology)Sciatic nerveExtracellular vesiclesFluorescence-lifetime imaging microscopyBiophysicsConjugated systemPeripheral nerveOptical imagingExtracellularBiomedical engineeringChemistryNanotechnologyMaterials scienceAnatomyCell biologyMedicineBiochemistryBiologyOpticsPolymerPhysicsBiotechnologyOrganic chemistryExtracellular vesicles in diseaseRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics