Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
REACCT Collaborative, Alexandra Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura d’Allens, Caterina Allmer, Andrea Álvarez, Rocío Anula, Mihailo Andric, S. Atallah, Simon P. Bach, Miklosh Bala, Marie Barussaud, Augustinas Baušys, Andrew D. Beggs, Felipe Bellolio, Melissa-Rose Bennett, Anton Berdinskikh, Vicki Bevan, Sebastiano Biondo, Gabriele Bislenghi, Marc Bludau, Nelleke P.M. Brouwer, Carl J. Brown, Christiane J. Bruns, Daniel D. Buchanan, Pamela Buchwald, Jacobus W. A. Burger, Никита Бурлов, Michela Campanelli, Maylis Capdepont, Michele Carvello, Hwee-Hoon Chew, Dimitri Christoforidis, David A. Clark, Marta Climent, Rowan Collinson, Kyle G. Cologne, Tomás Contreras, Roland S. Croner, I. R. Daniels, Giovanni Dapri, Justin Davies, Paolo Delrio, Quentin Denost, Michael Deutsch, André Roncon Dias, André D’Hoore, E. S. Drozdov, Daniel Duek, Malcolm G. Dunlop, Adam Dziki, Aleksandra Edmundson, Sergey Efetov, Alaa El‐Hussuna, Brodie Elliot, Sameh Hany Emile, Eloy Espín, Martyn Evans, Seraina Faes, Omar Faiz, Nuno Figueiredo, Fergal J. Fleming, Caterina Foppa, G Fowler, Matteo Frasson, Tim Forgan, Frank Frizelle, Shamil Gadaev, José Gellona, Tamara Glyn, Goran Barisic, Emma Greenwood, Marianne G. Guren, Stephanie Guillon, Ida Gutlic, Dieter Hahnloser, Heather Hampel, Ann Hanly, Hirotoshi Hasegawa, Lene Hjerrild Iversen, Andrew Hill, James Hill, Jiří Hoch, Roel Hompes, Luis Hurtado, Fabiano Iaquinandi, Ugnė Imbrasaitė, Rumana Islam, Mehrenah D Jafari, Andrea Jiménez Salido, Marta Jiménez Toscano, Yukihide Kanemitsu, А. М. Карачун, Ahmer Karimuddin, Deborah S. Keller, Justin Kelly, Rory Kennelly, Gleb Khrykov
Abstract
In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.