Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury
Kurt Bachmaier, Andrew Stuart, Abhalaxmi Singh, Amitabha Mukhopadhyay, Sreeparna Chakraborty, Zhigang Hong, Li Wang, Yoshikazu Tsukasaki, Mark Maienschein‐Cline, Balaji Ganesh, Prasad Kanteti, Jalees Rehman, Asrar B. Malik
Abstract
neutrophils produced inordinate amounts of reactive oxygen species and inflammatory chemokines and cytokines. Targeting this subset with ANP loaded with the drug piceatannol, a spleen tyrosine kinase (Syk) inhibitor, mitigated the effects of polymicrobial sepsis by reducing tissue inflammation while fully preserving neutrophilic host-defense function.
Topics & Concepts
SykInflammationChemokineImmunologyProinflammatory cytokinePopulationSpleenBiologyIn vivoCell biologyMedicineTyrosine kinaseSignal transductionEnvironmental healthBiotechnologyNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune Response and InflammationImmune cells in cancer