The human autophagy-initiating complexes ULK1C and PI3KC3-C1
Minghao Chen, James H. Hurley
Abstract
The unc-51-like kinase complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) are the key regulators of macroautophagy initiation. Understanding the assembly and coordination of these two complexes is essential for deciphering their cellular regulation and targeting them for therapeutic enhancement. This review highlights recent advances in our understanding of the structural organization and activation mechanisms of ULK1C and PI3KC3-C1 at the molecular level and discusses their roles within the protein interaction network governing autophagy initiation.
Topics & Concepts
AutophagyPhosphatidylinositolCell biologyKinaseMechanism (biology)BiologyChemistryComputational biologyBiochemistryPhysicsApoptosisQuantum mechanicsAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseCalcium signaling and nucleotide metabolism