LINC00982-encoded protein PRDM16-DT regulates <i>CHEK2</i> splicing to suppress colorectal cancer metastasis and chemoresistance
Huifang Hu, Lei Han, Jiaying Fu, Xuan He, Ji-Feng Tan, Qing-Ping Chen, Jing-Ru Han, Qing‐Yu He
Abstract
lncRNA LINC00982 can express a new protein PRDM16-DT to function as a novel regulator in cancer metastasis and drug resistance of CRC. Cimicifugoside H-1 can act on the upstream of the PRDM16-DT signaling pathway to alleviate cancer chemoresistance.
Topics & Concepts
CHEK2Colorectal cancerCancer researchMetastasisRNA splicingCarcinogenesisCancerBiologyMedicineGeneGeneticsMutationRNAGermline mutationCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing