Combination of chemotherapy and oxidative stress to enhance cancer cell apoptosis
Xinming Li, Yanan Hou, Jintao Zhao, Jin Li, Song Wang, Jianguo Fang
Abstract
The 1,2-diselenolane unit is a general scaffold to construct glutathione-dependent prodrugs that show increased potency to cancer cells, and work<italic>via</italic>a combination of chemotherapy and oxidative stress.
Topics & Concepts
Oxidative stressProdrugGlutathioneChemotherapyApoptosisCancerCancer cellCancer researchChemistryPharmacologyMedicineBiochemistryInternal medicineEnzymeSulfur Compounds in BiologyOrganoselenium and organotellurium chemistryRedox biology and oxidative stress