Targeting METTL3 enhances the chemosensitivity of non-small cell lung cancer cells by decreasing ABCC2 expression in an m<sup>6</sup>A-YTHDF1-dependent manner
Rui Zhang, Pu Chen, Yubo Wang, Zekun Zeng, Huini Yang, Mengdan Li, Xi Liu, Wei Yu, Peng Hou
Abstract
A-YTHDF1-dependent manner, and suggest that METTL3 may be a potential therapeutic target for acquired resistance to PTX or CBP in NSCLC.
Topics & Concepts
Cell cultureCancer researchCellDose dependenceLung cancerChemistryMolecular biologyBiologyCell biologyBiophysicsInternal medicineMedicineBiochemistryGeneticsRNA modifications and cancerCancer-related gene regulationCholangiocarcinoma and Gallbladder Cancer Studies