Co-encapsulation of paclitaxel and 5-fluorouracil in folic acid-modified, lipid-encapsulated hollow mesoporous silica nanoparticles for synergistic breast cancer treatment
Huanli Yin, Qi Yan, Yuan Liu, Lan Yang, Yang Liu, Yujie Luo, Tianyu Chen, Ningxi Li, Min Wu
Abstract
in a simulated tumor microenvironment. Moreover, the inhibitory effect of the dual-loaded nanoparticles was significantly better than that of the free drugs, suggesting that the composite nanosystem has the potential to selectively target tumor sites and perform the synergistic effect of PTX and 5-FU, while reducing their toxic effects on normal tissues.
Topics & Concepts
PaclitaxelChemistryMesoporous silicaFolic acidNanoparticleSolid lipid nanoparticleFolate receptorDrug deliveryMicroemulsionMesoporous materialControlled releaseLiposomeMicelleNanotechnologyPharmacologyBiophysicsCancer cellMaterials scienceBiochemistryAqueous solutionCancerOrganic chemistryMedicineCatalysisBiologyPulmonary surfactantInternal medicineNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsCancer, Lipids, and Metabolism