Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein
Michel A. Struwe, Bernd Clement, Axel J. Scheidig
Abstract
A study recently published in Hepatology Communications provided insights into a variant of MTARC1 protein, which conveys protection against liver disease. Here, we report a crystal structure of the variant protein at near-atomic resolution and compare it to the structure of the wildtype protein.
Topics & Concepts
Fold (higher-order function)HepatologyComputational biologyMedicineBioinformaticsBiologyComputer scienceInternal medicineProgramming languageRNA and protein synthesis mechanismsRNA regulation and diseaseMitochondrial Function and Pathology