Reproducible generation of human liver organoids (HLOs) on a pillar plate platform <i>via</i> microarray 3D bioprinting
Sunil Shrestha, Vinod Kumar Reddy Lekkala, Prabha Acharya, Soo‐Yeon Kang, Manav Goud Vanga, Moo‐Yeal Lee
Abstract
values calculated for sorafenib and tamoxifen were 6.2 ± 1.6 μM and 25.4 ± 8.3 μM, respectively. Therefore, our unique 3D bioprinting and miniature organoid culture on the pillar plate could be used for scale-up, reproducible generation of HLOs with minimal manual intervention for high-throughput assessment of compound hepatotoxicity.
Topics & Concepts
PillarOrganoid3D bioprintingForegutBiochipNanotechnologyHuman liverMicroarrayMaterials scienceChemistryCell biologyEngineeringBiologyBiomedical engineeringTissue engineeringAnatomyGeneIn vitroGene expressionBiochemistryStructural engineering3D Printing in Biomedical ResearchLiver physiology and pathologyCancer Cells and Metastasis