Role and function of granin proteins in diabetes mellitus
Zoltán Herold, Márton Doleschall, Anikó Somogyi
Abstract
autoantigens in type 1 diabetes, whereas pancreastatin (PST) and catestatin have regulatory effects in carbohydrate metabolism. Furthermore, PST is related to gestational and type 2 diabetes. CgB has a crucial role in physiological insulin secretion. Secretogranins II and III have angiogenic activity in diabetic retinopathy (DR), and are novel targets in recent DR studies. Ongoing studies are beginning to investigate the potential use of granin derivatives as drugs to treat diabetes based on the divergent relationships between granins and different types of diabetes.
Topics & Concepts
MedicineDiabetes mellitusFunction (biology)Type 2 Diabetes MellitusInternal medicineBioinformaticsEndocrinologyCell biologyBiologyHereditary Neurological DisordersCalpain Protease Function and RegulationToxin Mechanisms and Immunotoxins