In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism
Zhixuan Zhou, Konrad Maxeiner, Pierpaolo Moscariello, Siyuan Xiang, Yingke Wu, Yong Ren, Colette J. Whitfield, Lujuan Xu, Anke Kaltbeitzel, Shen Han, David Mücke, Haoyuan Qi, Manfred Wagner, Ute Kaiser, Katharina Landfester, Ingo Lieberwirth, David Y. W. Ng, Tanja Weil
Abstract
. The formed nanostructures blocked metabolic functions, including aerobic glycolysis and oxidative phosphorylation, thereby shutting down ATP production. As a consequence, ATP-dependent actin formation and glucose metabolite-dependent histone deacetylase activity are downregulated. We demonstrate that assembly-driven nanomaterials offer a rich avenue to achieve broad-spectrum bioactivities that could provide new opportunities in drug discovery.
Topics & Concepts
ChemistryBiochemistryCell biologySmall moleculeHomeostasisEnergy homeostasisOxidative phosphorylationBiophysicsNanotechnologyBiologyReceptorMaterials scienceSupramolecular Self-Assembly in MaterialsNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in Catalysis