Electrochemical Synthesis of Substituted Morpholines via a Decarboxylative Intramolecular Etherification
Ryosuke Yamada, Komei Sakata, Takahiro Yamada
Abstract
An efficient method for the synthesis of 2,6-multisubstituted morpholines via an electrochemical intramolecular etherification has been developed. The method, which is operationally simple and easy to scale up, provides various substituted morpholine derivatives in high yields. The utility of this method is showcased by the synthesis of 2,2,6,6-tetrasubstituted morpholines, which are difficult to synthesize efficiently using previously reported strategies.
Topics & Concepts
MorpholineChemistryIntramolecular forceCombinatorial chemistryElectrochemistryStereochemistryOrganic chemistryElectrodePhysical chemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsSynthesis and Catalytic Reactions