Hydro-phosphorothiolation of Styrene and Cyclopropane with <i>S</i>-Hydrogen Phosphorothioates under Ambient Conditions

Abstract

A metal-free hexafluoroisopropanol-mediated hydro-phosphorothiolation of styrenes and donor–acceptor cyclopropanes with S -hydrogen phosphorothioates in a Markovnikov fashion has been developed under ambient reaction conditions to afford a library of S -alkyl phosphorothioates. Notably, this strategy provides a simple and efficient way to produce biologically significant kitazin and iprobenfos derivatives. Mechanistic studies disclose that the reaction proceeds through a carbocation intermediate.

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