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Development of a simple and rapid method to determine the unbound fraction of dolutegravir, raltegravir and darunavir in human plasma using ultrafiltration and LC–MS/MS

Yi Zheng, Gabrielle Lui, Sana Boujaafar, Radia Aboura, Naïm Bouazza, Frantz Foissac, Jean‐Marc Tréluyer, Sihem Benaboud, Déborah Hirt, Inès Gana

2021Journal of Pharmaceutical and Biomedical Analysis11 citationsDOI

Topics & Concepts

RaltegravirChemistryDarunavirDolutegravirChromatographyTherapeutic drug monitoringUltrafiltration (renal)AnalytePharmacokineticsPharmacologyHuman immunodeficiency virus (HIV)Viral loadAntiretroviral therapyVirologyMedicineBiologyHIV/AIDS drug development and treatmentPharmacological Effects and Toxicity StudiesHIV Research and Treatment
Development of a simple and rapid method to determine the unbound fraction of dolutegravir, raltegravir and darunavir in human plasma using ultrafiltration and LC–MS/MS | Litcius