Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata
Shu-Ying Yu, Padmaja Paderu, Annie Lee, Sami Eirekat, Kelley R. Healey, Liang Chen, David S. Perlin, Yanan Zhao
Abstract
As an important and successful human pathogen, Candida glabrata is known for its swift adaptation and rapid acquisition of resistance to the most commonly used antifungal agents, resulting in therapeutic failure in clinical settings. Here, we describe that the histone acetyltransferase Gcn5 is a key factor in adapting to antifungal pressure and developing resistance in C. glabrata. The results provide new insights into epigenetic control over the drug response in C. glabrata and may be useful for drug target discovery and the development of new therapeutic strategies to combat fungal infections.
Topics & Concepts
Candida glabrataAcetylationDrug resistanceVirulenceAcetyltransferaseHistone acetyltransferaseBiologyRegulatorAntifungalHistoneMicrobiologyGeneticsGeneAntifungal resistance and susceptibilityFungal Infections and StudiesPeptidase Inhibition and Analysis