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Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Cian J. Lynch, Raquel Bernad, Ana Martínez‐Val, Marta N. Shahbazi, Sandrina Nóbrega‐Pereira, Isabel Calvo, Carmen Blanco‐Aparicio, Carolina Tarantino, Elena Garreta, Laia Richart-Ginés, Noelia Alcázar, Osvaldo Graña‐Castro, Gonzalo Goméz-López, Irène Aksoy, Maribel Muñoz‐Martín, Sonia Martı́nez, Sagrario Ortega, Susana Prieto, Elisabeth Simboeck, Alain Camasses, Camille Stephan‐Otto Attolini, Agustín F. Fernández, Marta Sierra, Mario F. Fraga, Joaquı́n Pastor, Daniel Fisher, Núria Montserrat, Pierre Savatier, Javier Muñoz, Magdalena Zernicka‐Goetz, Manuel Serrano

2020Nature Cell Biology65 citationsDOI

Topics & Concepts

EnhancerCyclin-dependent kinase 8Cell biologyBiologyKinaseMediatorRNA polymerase IITranscription factorPromoterGeneticsSignal transductionGene expressionGeneNotch signaling pathwayGenomics and Chromatin DynamicsCRISPR and Genetic EngineeringPluripotent Stem Cells Research
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases | Litcius