Immunization with the Gly<sup>1127</sup>-Cys<sup>1140</sup> amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies
Olga Bornachea, Aleyda Benitez‐Amaro, Àngela Vea, Laura Nasarre, David de Gonzalo‐Calvo, Juan Carlos Escola-Gil, Lídia Cedó, Antoni Iborra, Laura Martínez‐Martínez, C. Juárez, Juan A. Cámara, Carina Espinet, María Borrell-Pagés, Lina Badimón, Joan Martí i Castell, Vicenta Llorente‐Cortés
Abstract
: P3 immunization counteracts HFD-induced fatty streak formation in rabbits. The specific blockade of the LRP1 (CR9) domain with Anti-P3 Abs dramatically reduces HFD-induced intracellular CE loading and harmful coupling to pro-inflammatory signaling in the vasculature.
Topics & Concepts
InternalizationAntibodyImmunizationImmunohistochemistryAortaMedicineReceptorInternal medicineChemistryImmunologyEndocrinologyPathologyAtherosclerosis and Cardiovascular DiseasesCardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic Diseases