Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism
Sarah Madai, Pinar Kilic, Rolf M. Schmidt, Carlos Bas‐Orth, Thomas Korff, Michael Büttner, Glynis Klinke, Gernot Poschet, Hugo H. Marti, Reiner Kunze
Abstract
Collectively, our results indicate that HIF-1-mediated metabolic reprogramming alleviates the intrinsic vulnerability of brain-resident cells to ischemic stress.
Topics & Concepts
ReprogrammingHypoxia (environmental)Hypoxia-inducible factorsHypoxia-Inducible Factor 1Cell biologyMetabolismIschemic strokeChemistryMedicineNeuroscienceCancer researchBiologyCardiologyIschemiaInternal medicineTranscription factorBiochemistryOxygenGeneOrganic chemistryCancer, Hypoxia, and MetabolismMitochondrial Function and PathologyAdipose Tissue and Metabolism