Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6
Yehua Li, Jiayin Peng, Yuanxin Xia, Chenyu Pan, Yu Li, Weijie Gu, Jia Wang, Chaoxiong Wang, Yuang Wang, Jiawen Song, Xuan Zhou, Liya Ma, Yiao Jiang, Biao Liu, Qiongni Feng, Wenjia Wang, Shi Jiao, Liwei An, Dianfan Li, Zhaocai Zhou, Yun Zhao
Abstract
These findings implicated Sufu as an important inhibitor of TRAF6 in sepsis and suggest that therapeutics targeting Sufu-TRAF6 may greatly benefit the treatment of sepsis.
Topics & Concepts
InflammationProinflammatory cytokineLipopolysaccharideSepsisImmunologyMacrophageBlotWestern blotCancer researchMedicineIn vitroBiologyGeneBiochemistryImmune Response and InflammationNF-κB Signaling PathwaysCell death mechanisms and regulation