Garcimultiflins A–C, unusual polycyclic polyprenylated acylphloroglucinols from the pericarps of <i>Garcinia multiflora</i> as interleukin-1β and pyroptosis inhibitors
Jun Cao, Jiali Chen, Rongrong Du, Qingwen Zhang, Li‐She Gan, Pei‐Cheng Zhang, Ligen Lin
Abstract
Garcimultiflins A–C (1–3), three PPAPs with unusual skeletons, were isolated from the pericarps of Garcinia multiflora . Compound 2 blocks the secretion of IL-1β through suppressing the activation of NLRP3 inflammasome in THP-1 macrophages.
Topics & Concepts
ChemistryPyroptosisGarciniaInflammasomeStereochemistryTraditional medicineBiochemistryMedicineReceptorNatural Compound Pharmacology StudiesPhytochemistry and Biological ActivitiesSphingolipid Metabolism and Signaling