Emergence and Recovery of Ceftazidime-avibactam Resistance in<i>bla</i>KPC-33-Harboring<i>Klebsiella pneumoniae</i>Sequence Type 11 Isolates in China
Qingyu Shi, Dandan Yin, Renru Han, Yan Guo, Yonggui Zheng, Shi Wu, Yang Yang, Shirong Li, Rong Zhang, Fupin Hu
Abstract
This is the first report of ceftazidime-avibactam resistance caused by the blaKPC-33 mutation through the D179Y variant during the treatment of blaKPC-2-positive Klebsiella pneumoniae-related infections in China. The blaKPC-33-containing K. pneumoniae was susceptible to meropenem-vaborbactam, cefepime-zidebactam, tigecycline, and polymyxin B. The blaKPC-33 gene was located on a 77 551-bp transformable plasmid harboring qnrS1 and blaLAP-2. Detecting blaKPC-33-positive K. pneumoniae clinical strains is important for infection control.
Topics & Concepts
Klebsiella pneumoniaeCeftazidime/avibactamTigecyclineMicrobiologyMedicineCefepimePolymyxin BMeropenemPlasmidEnterobacteriaceaeVirologyBiologyAntibiotic resistanceImipenemAntibioticsGeneGeneticsEscherichia coliAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in Staphylococcus